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〔答〕氨苄青霉素(以下简称氨苄)是一种广谱新型青霉素,对革兰氏阳性菌和大部分革兰氏阴性菌都有较好抗菌效果,临床应用日益广泛,随之却又出现配合欠妥问题。经临床实践、文献记载和研究表明,氨苄水溶液稳定性较差,多元醇化合物如葡萄糖、右旋糖酐、甘露醇、山梨醇、转化糖及甘油等,对氨苄的分解有诱导和催化作用而降低其活性。多元醇化合物的浓度越大,静滴时间越长,气温越高,氨苄活性降低越显著,有时色变黄。改用生理盐水作溶媒,则较稳定。维生素 C 也是一种多元醇化合物,除可致上述变化外,它有较强的还原性,其水溶液稳定性也较差。维生素 C 注射液中含有还原性更强的稳定剂如焦亚硫酸钠或硫代硫酸钠等,均可使氨苄活性迅速降低。即使调整溶液 pH 值,也不能减少氨苄效价损失。故氨苄不宜与维生素 C、
〔A〕 ampicillin (hereinafter referred to as ampicillin) is a broad-spectrum new penicillin, Gram-positive bacteria and most of the Gram-negative bacteria have good antibacterial effect, clinical application of an increasingly widespread, followed by but with the emergence of Defective problem The clinical practice, the literature records and studies have shown that the less stable ampicillin aqueous solution, polyol compounds such as glucose, dextran, mannitol, sorbitol, invert sugar and glycerol, the induction of decomposition of benzyl and catalytic effect and reduce its activity . The greater the concentration of the polyol compound, the longer the infusion time, the higher the temperature, the more pronounced the reduction of the ampicillin activity and sometimes the color yellowing. Switch to saline for the solvent, the more stable. Vitamin C is also a polyhydric alcohol compound, in addition to these changes can be made, it has a strong reducing, its aqueous solution is also less stable. Vitamin C injection contains more reducible stabilizers such as sodium metabisulfite or sodium thiosulfate, etc., can make the rapid reduction of ampicillin activity. Even if the pH of the solution is adjusted, the amphetamine titer loss can not be reduced. Therefore, amphetamine should not be with vitamin C,