磷脂酶A_2及其生化检测研究进展

• 作 者: 颜光涛 徐世豪
• 机 构: 解放军304医院,解放军304医院
• 出 处: 国外医学.临床生物化学与检验学分册
• 发表日期: 1993年01期
• 关键词: 生化检测 磷脂酶 炎性疾病 脓毒败血症 脂解酶 三烯类 多脏器损伤 膜磷脂 前列腺素 生物因素

磷脂酶A_2是一种广泛存在于组织中的脂解酶。多种理化及生物因素均能促其激活而释放膜磷脂上的长链自由脂肪酸,后者成为前列腺素、白三烯类介质的前体。很多资料证明该酶在各种炎性疾病、脓毒败血症、休克和多脏器损伤中具有重要作用。本文拟对该酶的一般生物特性以及生化检测方法研究进展作一扼要综述。

Phospholipase A2 is a lipolytic enzyme widely found in tissues. A variety of physical and chemical and biological factors can promote its activation and release of long-chain free fatty acids on membrane phospholipids, which become prostaglandin, leukotriene precursors. A lot of data prove that this enzyme plays an important role in various inflammatory diseases, sepsis, shock and multiple organ damage. This article intends to give a brief overview of the general biological characteristics of the enzyme and biochemical detection methods.