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本文用胶体铁(CI)染色,电镜观察运动后及经GSH,VE和VC治疗的SD鼠(N=15)肾组织结构和肾小球毛细血管壁(GCW) 负电荷的变化,证实负荷游泳1/小时可损伤肾组织结构,使足突广泛融合,内皮孔径增大,线粒体肿胀破裂,严重时甚至可使GCW破裂。同时可使GCW固定负荷丢失,Ridit Analysis半定量分析提示内皮细胞CI染色和足突形态在游泳后16小时变化显著(X~2>x_(4-1)~2 0.05),GSH、VE和VC可阻止负荷游泳引发的自由基反应,减轻对紧组织结构和GCW负电荷的不利影响。
In this paper, the changes of renal tissue structure and the negative charge of glomerular capillary wall (GCW) in SD rats (N = 15) after exercise and after GSH, VE and VC treatment were observed by colloidal iron (CI) staining. 1 / hour can damage the renal tissue structure, so that a wide range of foot process fusion, increased endothelial diameter, mitochondria swelling rupture, even severe GCW rupture. At the same time, the fixed load of GCW could be lost. Semiquantitative analysis by Ridit Analysis showed that CI staining and foot process of endothelial cells changed significantly 16 hours after swimming (X ~ 2> x_ (4-1) ~ 2 0.05), GSH, VE and VC Can prevent the free radical reaction caused by the load swimming, and reduce the adverse effect on the tight tissue structure and the GCW negative charge.