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目的观察血清HBV标志物的变化,分析产前和产后联合阻断措施对HBsAg(+)、抗HBe(+)、抗HBc(+)孕妇及HBsAg(+)、HBeAg(+)、抗HBc(+)孕妇HBV母婴传播阻断的效果。方法收集2001年至2009年间孕产妇及其所娩新生儿的静脉血、初乳、脐血进行乙肝标志物检测与分析。结果 84例HBsAg(+)、抗HBe(+)、抗HBc(+)产妇初乳中HBsAg(+)检出率26.2%;32例HBsAg(+)、HBeAg(+)、抗HBc(+)产妇初乳HB-sAg(+)检出率93.8%,其中HBeAg(+)检出率56.3%。39例HBsAg(+)、抗HBe(+)、抗HBc(+)产妇所娩新生儿脐血HBsAg(+)检出率25.6%;18例HBsAg(+),HBeAg(+)、抗HBc(+)产妇所生新生儿脐血HBsAg(+)检出率55.6%,其中HBeAg(+)检出率50.0%。88例HBsAg(+)、抗HBe(+)、抗HBc(+)产妇所娩新生儿HBeAg(+)检出率1.1%,抗-HBs(+)检出率为60.2%;38例HBsAg(+)、HBeAg(+)、抗HBc(+)产妇所娩新生儿HBeAg(+)检出率18.4%,抗-HBs(+)检出率为52.6%。结论产前和产后联合阻断措施,能明显阻断HBV母婴传播的发生。
Objective To observe the change of serum HBV markers and analyze the effect of prenatal and postnatal combination therapy on HBsAg (+), anti-HBe (+), anti- HBc (+) pregnant women and HBsAg (+), HBeAg +) Effect of blockage of mother-to-child transmission of HBV in pregnant women. Methods The venous blood, colostrum and umbilical blood collected from pregnant women and their newborns from 2001 to 2009 were collected for the detection and analysis of hepatitis B markers. Results The positive rate of HBsAg (+) in colostrum of HBsAg (+), anti HBe (+) and anti HBc (+) in 84 cases was 26.2%; 32 cases of HBsAg +, HBeAg + Maternal colostrum HB-sAg (+) detection rate of 93.8%, of which HBeAg (+) detection rate of 56.3%. The detection rate of HBsAg (+) in cord blood of 39 newborns with HBsAg (+), anti HBe (+) and anti HBeB + was 25.6%; 18 HBsAg +, HBeAg + +) The detection rate of HBsAg (+) in neonates born to mothers was 55.6%, of which the detection rate of HBeAg (+) was 50.0%. The detection rate of HBeAg (+) was 1.1% and the anti-HBs (+) detection rate was 60.2% in 88 newborns with HBsAg (+), HBe HBeAg (+), HBeAg (+) and HBc (+) mothers gave birth to 18.4% of newborns and 52.6% of anti-HBs (+). Conclusion Prenatal and postnatal joint blockade can significantly block the occurrence of HBV mother-to-child transmission.