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将叶绿素-a溶解于乙酸并回流,一步剔除中心镁离子和脱去132-位甲氧酰基,再经重氮甲烷甲基化得到焦脱镁叶绿酸-a甲酯,再通过亲电加成、亲电取代、亲核加成、氧化、还原和消去等化学反应,实施对焦脱镁叶绿酸-a甲酯中3-位乙烯基1、31-位羰基、17-位尾端酯基和20-中位氢的活性反应位点,同时,对官能团保护的形成过程进行了探讨,并且提出了可能的反应机理.所得新化合物的化学结构经IR1,HNMR及元素分析予以确定.
The chlorophyll-a was dissolved in acetic acid and refluxed, one-step removal of central magnesium ion and deamination of 132-bit methoxyl group, and then methylated by diazomethane to obtain pyropheophorbide-a methyl ester, and then by electrophilic plus , Electrophilic substitution, nucleophilic addition, oxidation, reduction and elimination of the chemical reaction, the implementation of the focus pheophorbide-a methyl ester 3-position vinyl 1,31-carbonyl, 17-bit terminal ester At the same time, the formation process of functional group protection was discussed, and the possible reaction mechanism was proposed.The chemical structures of the new compounds obtained were confirmed by IR, HNMR and elemental analysis.