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用双环[2,2,1〕庚-5-烯-1,4,5,6,7,7-六氯-2,3-二酸酐与尿素共熔制备双环[2,2,1〕庚-5-烯-1,4,5,6,7,7-六氯-2,3-二酰亚胺.此酰亚胺与甲醛和胺(芳香及脂肪胺)在乙醇中反应,可生成N-曼尼希碱,且产率较高.用此法共制备了二十四个N-曼尼希碱,其中二十二个是新化合物.除了11及13号外(见表)都是在室温下获得的.硝基(对、邻)苯胺与甲醛及该酰亚胺的反应,在室温得到双(对、邻硝基苯胺基)甲烷,回馏一小时后亦可获得预期的N-曼尼希碱.先把该酰亚胺转变成N-羟甲基的衍生物,然后再与胺反应也可得到N-曼尼希碱.该酰亚胺与胺-甲醛缩合物反应,不需另加酸同样也生成N-曼尼希碱.
Bicyclo [2,2,1] hept-5-ene-1,4,5,6,7,7-hexachloro-2,3-dianhydride was co-melted with urea to prepare bicyclo [2,2,1] -5-ene-1,4,5,6,7,7-hexachloro-2,3-diimide. This imide reacted with formaldehyde and amines (aromatic and aliphatic amines) in ethanol to give N-Mannich base with high yield.Twenty-four N-Mannich bases were prepared by this method, of which twenty-two were new compounds except for Nos. 11 and 13 (see table) The reaction of nitro (para, o) aniline with formaldehyde and the imide at room temperature gives the bis (p, o-nitroanilino) methane at room temperature and the expected N - Mannich base first convert the imide into N-methylol derivatives, and then with the amine can also be obtained N-Mannich base of the imide amine-formaldehyde condensate reaction, N-Mannich bases are also generated without the addition of an acid.