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目的：对正常大肠、结肠炎、大肠腺瘤、腺瘤癌变、大肠癌及癌旁组织ＡｇＮＯＲ 进行定量研究，探讨其临床意义。方法：采用胶体银染技术对大肠良恶性上皮细胞中ＡｇＮＯＲ 染色，于显微镜下计数。良性疾病为炎症１０ 例，腺瘤１２ 例，恶性疾病为腺瘤癌变９ 例，腺癌１３ 例。正常对照８ 例。结果：正常、炎症及癌旁组织、腺瘤组织ＡｇＮＯＲ 计数低于癌组织（ Ｐ＜ ０－０１） ，腺瘤组织ＡｇＮＯＲ 计数高于正常、炎症及癌旁组织（ Ｐ＜ ０－０５） ，腺癌术后生存３ 年以上者与１ 年内复发死亡者癌组织ＡｇＮＯＲ 计数无差别。结论：ＡｇＮＯＲ计数有助于鉴别大肠良恶性疾病，对判断预后无价值，大肠腺瘤应及时切除。
OBJECTIVE: To study the quantitative significance of normal colorectal, colitis, colorectal adenoma, adenoma, colorectal cancer, and adjacent normal tissue AgNOR. METHODS: AgNOR staining was performed on benign and malignant epithelial cells of the large intestine using colloidal silver staining technique and counted under a microscope. The benign disease was inflammation in 10 cases, adenoma in 12 cases, malignant disease in 9 cases of adenoma carcinogenesis, and adenocarcinoma in 13 cases. 8 normal controls. Results: AgNOR counts in normal, inflammatory, paracancerous, and adenoma tissues were lower than those in cancer tissues (P < 0-01). AgNOR counts in adenomas were higher than normal, inflammation, and adjacent tissues (P < 0-05). There was no difference in AgNOR counts between cancer patients who survived for more than 3 years after surgery and those who relapsed within 1 year. Conclusion: AgNOR count is helpful to distinguish between benign and malignant colorectal diseases. It is not worth judging the prognosis. Colorectal adenoma should be promptly removed.