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目的探讨介入性产前诊断在预防出生缺陷中的作用及其安全性、有效性。方法回顾2009年9月至2010年11月在本院进行产前诊断的2877例病例。并对所有病例进行电话随访至分娩后。结果检出胎儿重型α-地中海贫血及重型β-地中海贫血共42例,中间型α-地中海贫血17例,胎儿染色体异常86例。130个胎儿引产终止妊娠。术后2周内胎儿丢失率:羊膜腔穿刺为0.33%,脐带穿刺为0.26%。结论介入性产前诊断是安全、有效的诊断胎儿严重出生缺陷的重要方法。
Objective To explore the role of interventional prenatal diagnosis in the prevention of birth defects and its safety and efficacy. Methods The 2877 cases of prenatal diagnosis in our hospital from September 2009 to November 2010 were reviewed. All patients were followed up by telephone until after childbirth. Results A total of 42 cases of severe α-thalassemia and β-thalassemia major were detected in fetuses, 17 cases of intermediate α-thalassemia and 86 cases of fetal chromosomal abnormalities. 130 fetuses abortion termination of pregnancy. Fetal loss rate within 2 weeks after surgery was 0.33% for amniocentesis and 0.26% for umbilical cord aspiration. Conclusion Interventional prenatal diagnosis is a safe and effective method for the diagnosis of severe birth defects in fetuses.