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普萘洛尔治疗婴幼儿血管瘤(IH)已经被广泛接受。该文作者旨在对药物治疗的安全性进行系统回顾与评价。对Embase和Medline数据库2007-2014年间相关文献进行检索,纳入研究的文献包括样本量≥10且治疗过程中出现副作用(AE)的样本数≥1。结果:在检索的398篇文献中,符合纳入标准的文献为83篇,包括5862例接受普萘洛尔治疗的患儿,1945例出现AE的患儿。最常见的AE包括睡眠紊乱、四肢厥冷和躁动。最严重的AE包括房室传导阻滞、心动过缓、低血压、支气管痉挛及低血糖引起的
Propranolol has been widely accepted for the treatment of infantile hemangiomas (IH). The authors aim to systematically review and evaluate the safety of drug treatment. Literature related to the Embase and Medline databases for 2007-2014 was searched and included in the literature included samples with a sample size ≥10 and with side effects (AE) ≥ 1 during the course of treatment. Results: Of the 398 retrieved articles, 83 articles met the inclusion criteria, including 5862 children treated with propranolol and 1945 children with AE. The most common AEs include sleep disorders, extremities and cold and restlessness. The most severe AEs include atrioventricular block, bradycardia, hypotension, bronchospasm, and hypoglycemia