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目的:探讨新疆哈萨克族脑梗死与细胞黏附分子1(ICAM-1)G241R基因多态性的关系。方法:采用多聚酶链式反应法及限制性内切酶片段长度多态性技术,对新疆哈萨克族100例脑梗死患者及110例健康者(对照组)进行ICAM-1基因G241R多态性检测,比较不同基因型与哈萨克族脑梗塞发病风险的关系。结果:脑梗塞患者ICAM-1基因G41R多态性的基因型频率和等位基因频率与健康对照组相比无明显差异。结论:ICAM-1基因G214R多态性可能不是新疆哈萨克族脑梗塞发病的遗传学危险因素。
Objective: To investigate the relationship between Xinjiang Kazak cerebral infarction and cell adhesion molecule 1 (ICAM-1) G241R polymorphism. Methods: Polymerase chain reaction (PCR) and restriction fragment length polymorphism (PCR-RFLP) were used to detect the G241R polymorphism of ICAM-1 gene in 100 Kazakh patients with cerebral infarction and 110 healthy controls (control group) To compare the relationship between different genotypes and the risk of developing cerebral infarction in Kazakh. Results: There was no significant difference in the genotype frequency and allele frequency of ICAM-1 gene G41R polymorphism in patients with cerebral infarction compared with healthy controls. Conclusion: The G214R polymorphism of ICAM-1 gene may not be a genetic risk factor for the onset of cerebral infarction in Xinjiang Kazak.