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在生产静脉注射免疫球蛋白 (IVIG)的工艺中 ,p H4条件下胃蛋白酶处理的方法已被很多欧洲厂家采用。本文介绍了以 Cohn组分 作为蛋白来源生产 IVIG的方法。 具体工艺流程为 : 1.增加巴氏消毒法 :6 0℃加热 10小时 ,并加入高浓度 (33% )的山梨糖醇做稳定剂。快速蛋白质液
In the process of producing intravenous immunoglobulin (IVIG), pepsin treatment under p H4 conditions has been adopted by many European manufacturers. This article describes a method for producing IVIG using the Cohn component as a protein source. The specific process is as follows: 1. Increase the pasteurization method: heating at 60 ° C. for 10 hours and adding high concentration (33%) of sorbitol as a stabilizer. Fast protein solution