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温敏性聚合物在组织工程、药物传递和缓释、生物传感器以及纳米药物中有着广泛的应用。聚N-异丙基丙烯酰胺,聚甲基丙烯酸寡聚乙二醇酯以及吡咯烷酮基聚合物是典型的温敏性聚合物。然而,这些温敏性聚合物功能相对单一。现代科技的发展,对温敏性材料提出了新的要求,如具有多重刺激响应特性、生物相容性好、可生物降解以及其他功能。氨基酸是两性分子,具有手性、生物相容性好、多官能团、二级结构丰富等优点。以氨基酸或多肽构筑温敏聚合物可以将聚合物的多样性与氨基酸的优点结合起来,本文介绍了此类材料的合成及研究进展。
Temperature-sensitive polymers are widely used in tissue engineering, drug delivery and sustained release, biosensors and nanomedicine. Poly N-isopropylacrylamide, polymethacrylic oligoglycollate, and pyrrolidone-based polymers are typical temperature-sensitive polymers. However, these temperature-sensitive polymers have a relatively single function. The development of modern science and technology poses new requirements for temperature-sensitive materials, such as multiple stimulation response characteristics, good biocompatibility, biodegradability and other functions. Amino acids are amphiphilic molecules with chirality, good biocompatibility, multi-functional groups, secondary structure and other advantages. The construction of temperature-sensitive polymers with amino acids or peptides can combine the diversity of polymers with the advantages of amino acids. The synthesis and research progress of these materials are introduced in this paper.