论文部分内容阅读
目的探讨小剂量米非司酮联合中草药治疗子宫肌瘤与单纯使用小剂量米非司酮治疗子宫肌瘤的临床疗效比对分析,了解其安全性及临床可行性。方法昌黎县人民医院确诊的100例子宫肌瘤患者,随机选出50例为试验组,50例为对照组。试验组:给予小剂量米非司酮12.5 mg/d,联合中草药(夏枯草、柴胡、丹参等)治疗子宫肌瘤,每日1剂,20 d为1个疗程,间隔10 d后再服,连用3个月;对照组:单纯用小剂量米非司酮12.5 mg/d,连用3个月为1疗程。对两组患者进行临床观察与对比。服药期间,忌食腥、酸、辣、酒、生冷等食物。结果试验组与对照组临床观察存在显著差异,试验组子宫与瘤体缩小程度明显,贫血得以改善,雌孕激素含量下降优于对照组。与对照组比较,差异有统计学意义(P<0.05)。结论与单纯用米非司酮相比,小剂量米非司酮结合中草药治疗子宫肌瘤,可以提高女性生活质量,不良反应小,疗效确切,值得临床推广。
Objective To investigate the clinical efficacy of low-dose mifepristone combined with Chinese herbal medicine in the treatment of uterine fibroids and simple use of low-dose mifepristone in the treatment of uterine fibroids, and to investigate its safety and clinical feasibility. Methods Changli County People’s Hospital diagnosed 100 cases of uterine fibroids, randomly selected 50 cases for the experimental group, 50 cases for the control group. The experimental group: given a small dose of mifepristone 12.5 mg / d, combined with Chinese herbal medicine (Prunella, Bupleurum, Salvia, etc.) for the treatment of uterine fibroids, 1 day, 20 d for a course of treatment, , Once every 3 months; control group: only a small dose of mifepristone 12.5 mg / d, once every 3 months for a course of treatment. Two groups of patients for clinical observation and comparison. During medication, avoid eating fishy, sour, spicy, alcohol, cold and other food. Results There was a significant difference between the experimental group and the control group in clinical observation. The degree of uterus and tumor shrinkage was significant in the experimental group, anemia was improved, and the level of estrogen and progesterone in the test group was better than that in the control group. Compared with the control group, the difference was statistically significant (P <0.05). Conclusion Compared with the simple use of mifepristone, low dose mifepristone combined with Chinese herbal medicine for the treatment of uterine fibroids can improve the quality of life of women with little adverse reactions, and the curative effect is worthy of clinical promotion.