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我们研发的脉冲性关节机械刺激是以一定加载频率对大鼠滑膜关节如肘、膝和踝进行的机械刺激,可以引起骨的相关合成代谢反应。前期研究证实,关节机械加载通过Wnt3a/Lrp5、OPG等信号通路,诱导大鼠骨髓间充质干细胞分化,调控血管内皮细胞并促使血管生成;同时抑制破骨细胞骨吸收,促进成骨细胞骨形成,使骨重建和血管重建偶联作用,治疗骨科相关疾病。例如,肘关节机械刺激能促进大鼠上肢尺骨和肱骨的纵向延长;膝关节机械刺激能够通过
The pulsed joint mechanical stimulation we developed is a mechanical stimulation of the synovial joints of the rats, such as the elbow, knee and ankle, at a certain loading frequency and can cause bone-related anabolic responses. Previous studies confirmed that mechanical loading of joints through Wnt3a / Lrp5, OPG and other signaling pathways, induced rat bone marrow mesenchymal stem cell differentiation, regulation of vascular endothelial cells and promote angiogenesis; while inhibiting osteoclast bone resorption and promote osteoblastic bone formation , Bone remodeling and reconstruction of the role of coupling, treatment of orthopedic related diseases. For example, mechanical stimulation of the elbow can promote longitudinal extension of the upper extremity ulna and humerus; mechanical stimulation of the knee can pass