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[目的]探讨外周血血小板(PLT)计数及血浆纤维蛋白原(FIB)与上皮性卵巢癌生物学行为的关系。[方法]回顾性分析上皮性卵巢癌初次手术病例82例,并与同期收治的52例卵巢良性肿瘤作对照,比较两组术前血小板计数和纤维蛋白原含量。同时分析血小板计数和纤维蛋白原含量与上皮性卵巢癌生物学行为的关系。[结果]术前上皮性卵巢癌患者血小板计数增高者占52.44%,良性肿瘤中占11.54%;在上皮性卵巢癌中血浆纤维蛋白原增高者占53.66%,而良性肿瘤中占7.69%,差异均有统计学意义(P=0.000)。血小板计数与上皮性卵巢癌的FIGO分期、腹水、分化程度、是否行理想的肿瘤细胞减灭术有关(P<0.05),与CA125及病理类型无关。血浆纤维蛋白原与上皮性卵巢癌的各项临床病理因素均无关(P>0.05)。单因素及多因素分析结果显示血小板计数及纤维蛋白原均与卵巢癌复发无关。[结论]血小板计数增高可能是反映上皮性卵巢癌浸润程度的指标。纤维蛋白原增高可能是卵巢癌的结果,其与血小板的关系有待于进一步研究。
[Objective] To investigate the relationship between peripheral blood platelet (PLT) count, plasma fibrinogen (FIB) and biological behavior of epithelial ovarian cancer. [Methods] 82 cases of primary surgery for epithelial ovarian cancer were retrospectively analyzed, and compared with 52 cases of benign ovarian tumors treated in the same period. The preoperative platelet count and fibrinogen content were compared between the two groups. The relationship between platelet count and fibrinogen level and the biological behavior of epithelial ovarian cancer was also analyzed. [Results] The preoperative epithelial ovarian cancer patients with elevated platelet count accounted for 52.44%, benign tumors accounted for 11.54%; epithelial ovarian cancer in plasma fibrinogen increased accounted for 53.66%, while benign tumors accounted for 7.69%, the difference All were statistically significant (P = 0.000). Platelet count was correlated with FIGO staging, ascites, degree of differentiation, and ideal cytoreductive surgery (P <0.05), but not with CA125 and pathological type. There was no correlation between plasma fibrinogen and clinicopathologic factors of epithelial ovarian cancer (P> 0.05). Univariate and multivariate analysis showed that platelet count and fibrinogen had no correlation with recurrence of ovarian cancer. [Conclusion] Increased platelet count may be an indicator of the degree of epithelial ovarian cancer infiltration. Increased fibrinogen may be the result of ovarian cancer, its relationship with platelets needs further study.