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胃癌的发病率在世界范围内占恶性肿瘤的第四位[1],胃癌是男性肿瘤的第二死亡原因,是女性肿瘤的第一死亡原因,胃癌的病因学一直为国内外学者所重视,认为可能与遗传、饮食、环境及生物等多种因素有关。EBV与很多的恶性肿瘤有关,如Burkitt淋巴瘤、经典的Hodgkin淋巴瘤、鼻咽癌、喉癌。其中EBV是引起胃癌的重要生物学因素之一,尤其是胃腺癌,1993年Tokunaga等将经EBER-ISH证实胃癌细胞EBER阳性者定义为EBV相关胃癌,很多学者对EBV的致癌机制进行
The incidence of gastric cancer in the world accounting for the fourth in malignant tumors [1], gastric cancer is the second leading cause of death of men is the first cause of death of female cancer, etiology of gastric cancer has been valued by scholars at home and abroad, That may be related to genetic, diet, environmental and biological and other factors. EBV is associated with many malignancies, such as Burkitt’s lymphoma, classic Hodgkin lymphoma, nasopharyngeal cancer, and laryngeal cancer. EBV is one of the important biological factors that cause gastric cancer, especially gastric adenocarcinoma. In 1993, Tokunaga et al. Defined EBER-positive gastric cancer cells by EBER-ISH as EBV-related gastric cancer, and many scholars conducted oncogenic mechanisms of EBV