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目的分析院内感染病原微生物的分布及耐药性，为控制和预防院内感染、合理使用抗菌药物提供依据。方法回顾性分2011~2013年我院260例院内感染患者的临床析20资料，分析病原微生物的分布情况并对其耐药性进行检测。结果260例院内感染患者共检出438株病原菌，其中，革兰阳性菌124株(28.31%)以金黄色葡糖球菌为主，革兰阴性菌232株(52.97%)，以大肠埃希菌、铜绿假单胞菌为主，真菌82株(18.72%)，以热带假丝酵母菌为主；革兰阳性菌对青霉素、左氧氟沙星、克林霉素、红霉素的耐药性较高，革兰阴性菌对第三代头孢菌素、喹诺酮类和氨基糖苷类等抗菌药物耐药率较高，真菌对抗菌药物的耐药性普遍较低。结论院内感染病原微生物主要是革兰阴性菌，且耐药性较强，临床应根据院内感染病原微生物的分布及耐药性分析结果制定合理、有效的给药方案，从而提高药物的抑菌作用，减少耐药菌的产生与传播，对于控制院内感染的发生具有重要意义。“,”Objective To analyze the distribution and drug resistance of nosocomial infection of pathogenic,and provide the basis for rational use of antimicrobial drugs to control and prevent nosocomial infections.Methods A retrospective analysis of 260 cases of nosocomial infection patients from 2011 to 2013 in our hospital,clinical data was analyzed to find the distribution of pathogens and their drug resistance.Results 260 cases of nosocomial infections were detected in 438 patients with pathogens,including gram-positive bacteria 124 (28.31%)and Staphylococcus aureus glucose was the majority, gram-negative bacteria 232 (52.97%),and Escherichia bacteria,Pseudomonas aeruginosa were the majority,fungi 82 (18.72%),mainly to Candida tropicalis;Gram-positive bacteria had strong resistance to penicil in,levofloxacin,clindamycin,erythromycin and Gram-negative bacteria had strong resistance to third-generation cephalosporins,fluoroquinolones and aminoglycosides while fungal had low resistance to antimicrobial drugs.Conclusion The nosocomial infection pathogens are mainly Gram-negative bacteria which has strong resistance.Therefore,in clinic reasonable and ef ective dosing regimen should be developed based on the distribution of nosocomial infection pathogens and drug resistance analysis,thereby enhancing antimicrobial drugs role in reducing the generation and spread of resistant bacteria,which is important for the control of nosocomial infection.