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异位骨化早为许多学者所报导。Huggin首先指出用尿路移行上皮作自体移植可导致异位骨化。之后,Leriche、Friedenstein等许多学者证明:移行上皮诱导的成骨活动较其它方法诱导异位骨化所需时间短而成效高。Gosset指出异体移植不能诱导骨化。但Jehnson和Mc Minn等用猫作异体移植的试验,证明也能诱导骨化,但成骨率较低。近些年有人报导用异种移植的成骨效果很差。许多学者对异体和异种移植导致成骨不恒定的原因持不同的见解,一般接受Medawar的抗原抗体免疫反应学说。关于移行上皮诱导骨化的机制至今未被阐明。移行上皮诱导骨化的因素究竟是什
Heterotopic ossification has long been reported by many scholars. Huggin first pointed out that the use of urothelial transitional autograft can lead to heterotopic ossification. Later, many scholars such as Leriche and Friedenstein proved that the transitional epithelium-induced osteogenic activity is more effective than other methods in inducing heterotopic ossification. Gosset pointed out that allotransplantation can not induce ossification. But tests such as Jehnson and Mc Minn using cadaveric allografts proved that ossification can also be induced, but osteogenic rates are low. In recent years, it has been reported that xenograft osteogenesis is poorly effectuated. Many scholars hold different opinions on the reasons why allogeneic and xenotransplantation lead to osteogenesis, and generally accept Medawar’s theory of antigen-antibody immunoreactivity. The mechanism of transitional epithelium-induced ossification has not been elucidated so far. What are the factors that induce epithelial ossification?