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The aim of this study was to compare predictions of hyperbilirubinaemia by eye , performed by trained physicians and nurses, with predictions obtained using tw o commercial bilirubinome-ters. Jaundice was assessed in 92 white and 48 non-w hite healthy full-term neonates using three non-invasive methods and by total serum bilirubin as the reference method. Clinical assessment of cephalocaudal pr ogression of jaundice was carried out independently by a physician and by nurses . Simultaneously, the Minolta Airshields JM-102 was applied on the sternum, the BiliCheck on both the forehead and the sternum, and finally, serum bilirubin co ncentrations were determined. The Minolta JM-102 showed the best performance wi th r2 = 0.90, an intraclass correlation coefficient (ICC) of 0.93, and a 95%c onfidence interval (CI) of ±4 units (approx. 56 μmol/l). The BiliCheck perform ed slightly better on the forehead than over the sternum with r2 = 0.90, an ICC of 0.88, and a CI of ±62 μmol/l. Assessment of jaundice by eye was least acc urate with r2 = 0.74, an ICC of 0.67, and a CI of ±1.5 zones (corresponding to ±75 μmol/l). Skin pigmentation and ambient light both adversely affected no n-invasive bilirubin estimation. Conclusion: All three non-invasive methods ar e well suited for estimation of serum bilirubin but show large confidence interv als. In healthy term newborns, hyperbilirubinaemia ( > 250 μmol/l) can be safel y ruled out by eye if jaundice does not reach the abdomen or the extremities (Kr amer zones 1 and 2), with < 22 units ( < 230 μmol/l) for the Minolta JM-102, o r with a cut-off of 190 μmol/l for the BiliCheck. If these respective threshol ds are exceeded, serum bilirubin concentrations should be measured.
The aim of this study was to compare predictions of hyperbilirubinaemia by eye, performed by trained physicians and nurses, with predictions obtained using tw o commercial bilirubinome-ters. Jaundice was assessed in 92 white and 48 non-w hite healthy full-term neonates using three non-invasive methods and by total serum bilirubin as the reference method. Clinical assessment of cephalocaudal pr ogression of jaundice was carried out separately from a physician and by nurses. Simultaneously, the Minolta Airshields JM-102 was applied on the sternum, the BiliCheck on both the forehead and the sternum, and finally, serum bilirubin co ncentrations were determined. The Minolta JM-102 showed the best performance wi th r2 = 0.90, an intraclass correlation coefficient (ICC) of 0.93, and a 95% c onfidence interval (CI) of ± 4 units (approx. 56 μmol / l). The BiliCheck perform ed slightly better on the forehead than over the sternum with r2 = 0.90, an ICC of 0.88, and a CI of ± 62 μmol / ent of jaundice by eye was least acc urate with r2 = 0.74, an ICC of 0.67, and a CI of ± 1.5 zones (corresponding to ± 75 μmol / l). Skin pigmentation and ambient light both adversely affected no n-invasive bilirubin . All three non-invasive methods ar e well suited for estimation of serum bilirubin but show large confidence interv als. In healthy term newborns, hyperbilirubinaemia (> 250 μmol / l) can be safel y ruled out by eye if jaundice does not with the cut-off of 190 μmol / l for the BiliCheck. These these retractable or extremities (Kr amer zones 1 and 2), with <22 units (<230 μmol / l) for the Minolta JM- respective threshol ds are exceeded, serum bilirubin concentrations should be measured.