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最近的研究表明,尿蛋白的选择性可作为 IgA 肾炎的预后指标。本文旨在对 IgA 肾炎患者尿蛋白的选择性和疾病预后、治疗反应以及疾病发展过程中选择指数(SI)的波动等进行研究。129例经肾活检证实的 IgA 肾炎患者,除31例尿蛋白量过少而无法进行 SI 测定,余98例作了 SI 测定。IgA 肾炎主要根据肾活检、免疫荧光以 IgA 免疫球蛋白为主的系膜区沉积而诊断,且排除系统性红斑狼疮、过敏性紫癜、肝硬化和全身性血管炎。共随访4年,观察血压、血尿、24小时尿蛋白定量、血清肌酐和肌酐清除率(Ccr)的变化。
Recent studies have shown that urinary protein selectivity can be used as a prognostic indicator of IgA nephritis. This article aims to investigate urinary protein selectivity and prognosis of patients with IgA nephritis, treatment response, and selection index (SI) fluctuations during disease progression. 129 patients with IgA nephritis confirmed by renal biopsy, in addition to 31 cases of urinary protein was too small to measure SI, the remaining 98 cases were SI determination. IgA nephritis is mainly based on renal biopsy, immunofluorescence IgA immunoglobulin-based mesangial deposition and diagnosis, and rule out systemic lupus erythematosus, Henoch-Schonlein purpura, cirrhosis and systemic vasculitis. A total of 4 years follow-up were observed blood pressure, hematuria, 24-hour urine protein, serum creatinine and creatinine clearance rate (Ccr) changes.