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环孢素 A(CsA)是一种有效的新型免疫抑制剂,以往虽有报道 CsA 对常规免疫抑制剂治疗无效的顽固性蛋白尿有效,但作用机制未明。17例患者(男13,女4)平均年龄25岁,其中14例为难治性肾病综合征,对强的松和/或免疫抑制剂无效。病理诊断膜性肾炎(IMGN)6例,局灶节段肾小球硬化(FSGS)3例,微小病变性肾炎(MCD)3例,膜增殖性肾炎(MPGN)2例,另3例为 Alport’s综合征(遗传性耳聋肾病综合征,AS)患者。CsA
Cyclosporine A (CsA) is a potent new immunosuppressant. Although CsA has been reported to be effective in the treatment of refractory proteinuria with conventional immunosuppressive drugs, its mechanism of action is unknown. Seventeen patients (13 males and 4 females) averaged 25 years of age, of whom 14 were refractory to nephrotic syndrome and did not respond to prednisone and / or immunosuppressive agents. Pathological diagnosis of membranous nephritis (IMGN) in 6 cases, 3 cases of focal segmental glomerulosclerosis (FSGS), 3 cases of minimally invasive nephritis (MCD), 2 cases of membranoproliferative nephritis (MPGN), the other 3 cases of Alport’s Syndrome (hereditary deafness nephrotic syndrome, AS) patients. CsA