【摘 要】
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Dear Editor,Histone deacetylase 6 (Hdac6) was discovered as a deacetylase of α-tubulin and functions in cell migration,immunity and resistance to virus infecti
【机 构】
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State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center for Biotherapy,
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Dear Editor,Histone deacetylase 6 (Hdac6) was discovered as a deacetylase of α-tubulin and functions in cell migration,immunity and resistance to virus infection in vitro (Hubbert et al.,2002;Valenzuela-Feandez et al.,2008).Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem (ES) cells and in mice (Wang et al.,2015).Hdac6 also can function to deacetylate protein and is involved in protein ubiquitination and degradation (Seigneurin-Bey et al.,2001;Zhang et al.,2014),and selfclearance of misfolded proteins,promoting autophagy and preventing neurodegeneration (Lee et al.,2010;Pandey et al.,2007).HDAC6 also is implicated in DNA damage response and depletion or inhibition of HDAC6 induces DNA damage and apoptosis (Namdar et al.,2010;Zhang et al.,2014),suggesting that HDAC6 could be important for DNA repair and integrity maintenance.
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