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目的旨在探讨听神经动作电位（ＡＰ）与耳蜗内电位（ＥＰ）之间是否存在着一定的对应的关系。方法经豚鼠颈静脉注入速尿与小牛血清白蛋白混合液，同步记录ＥＰ和ＡＰ。ＥＰ由耳蜗基底周引出，ＡＰ以１０５ｄＢｐｅＳＰＬ短声诱发，面神经管电极记录。对ＡＰ百分比振幅与ＥＰ幅值进行相关性分析。结果ＡＰ百分比振幅与ＥＰ幅值呈高度的正相关（ｒ＞０．９），两者为明确的“Ｓ”型对应关系。当ＥＰ值在６０～７０ｍＶ以上时，ＡＰ振幅能保持在８０％以上；当ＥＰ值从６０ｍＶ降至４０ｍＶ，或从３０ｍＶ上升至７０ｍＶ时，ＡＰ振幅变化急剧；当ＥＰ值低于３０ｍＶ时，ＡＰ则趋于消失。结论提示当ＥＰ受有害因素影响而不低于６０～７０ｍＶ时，耳蜗仍能保持一定程度的生理活性
The purpose is to investigate whether there is a certain correspondence between auditory nerve action potential (AP) and intra-cochlear potential (EP). Methods The guinea pig jugular vein was infused with mixed solution of furosemide and bovine serum albumin to record EP and AP simultaneously. EP lead from the base of the cochlear week, AP to 105dBpeSPL short-tone induced facial nerve electrode recording. The correlation between AP amplitude and EP amplitude was analyzed. Results The percent amplitude of AP was highly positively correlated with the amplitude of EP (r> 0.9), and the two showed a clear “S” correspondence. When the EP value is above 60 ~ 70mV, the amplitude of AP can maintain more than 80%. When the value of EP decreases from 60mV to 40mV or from 30mV to 70mV, the amplitude of AP changes sharply. When the value of EP is lower than 30mV, It tends to disappear. Conclusion suggests that when EP is affected by harmful factors and not less than 60 ~ 70mV, the cochlea can still maintain a certain degree of physiological activity