Liquid chromatography-tandem mass spectrometry method for the estimation of adefovir in human plasma

• 作 者: Dipanjan Goswami Sanjay Gurule
• 机 构: SunPharmaceuticalindustriesLtd.,DepartmentofClinicalPharmacologyandPharmacokinetics
• 出 处: 药物分析学报：英文版
• 发表日期: 2015年3期
• 关键词: 液相色谱-串联质谱法 人血浆 药代动力学 应用 阿德福韦酯 估计 质谱检测 基体效应 Liquid chromatography-tandem massspec
• 基金项目: The authors wish to acknowledge the support and facilities received from Ranbaxy Research Laboratories Gurgaon, India, for carrying out this work. Usual disclaimer applies.

An analytical method based on solid phase extraction was developed and validated for analysis of adefovir in human plasma.Adefovir-d4 was used as an internal standard and Synergi MAX RP80A（150 mm × 4.6 mm,4 μm） column provided the desired chromatogra