Multi-spectroscopic investigation of the binding interaction of fosfomycin with bovine serum albumin

• 作 者: Manjunath D. Meti Sharanappa T
• 机 构: PostGraduateDepartmentofStudiesinChemistry,NovelDrugDesignandDiscoveryLaboratory
• 出 处: 药物分析学报：英文版
• 发表日期: 2015年4期
• 关键词: 牛血清白蛋白 相互作用 磷霉素 多光谱 同步荧光光谱 三维荧光光谱 静态猝灭 分子模拟 FosfomycinSerum albuminSpectroscopic
• 基金项目: One of the authors Manjunath D. Meti expresses gratitude to DST New Delhi for providing Innovation in Science Pursuit for Inspired Research （INSPIRE） fellowship （IF110S48）.

The interaction between fosfomycin(FOS) and bovine serum albumin(BSA) has been investigated effectively by multi-spectroscopic techniques under physiological p H 7.4. FOS quenched the intrinsic fl uorescence of BSA via static quenching. The number of bind