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目的探讨分泌性免疫球蛋白Ａ（ｓＩｇＡ）在幽门螺杆菌（ＨＰ）导致的慢性浅表性胃炎中的作用。方法选取慢性浅表性胃炎患者６３例，按组织学分型分为轻、中、重度胃炎；按有无中性粒细胞的出现分为活动性和非活动性胃炎，采用放射免疫法测定ｓＩｇＡ，ＨＰ检出采用尿素酶试验及 Ｗａｒｔｈｉｎ－Ｓｔａｒｒｙ染色。 结果慢性浅表性胃炎患者幽门螺杆菌检出率为 ４９．２１％。 ＨＰ阳性胃炎患者胃液中 ｓＩｇＡ浓度显著高于 ＨＰ阴性者。轻度胃炎者明显低于中、重度者，差异极显著（Ｐ＜０．００１）。ＨＰ阳性活动性胃炎患者胃液明显高于ＨＰ阳性非活动性胃炎患者。结论ＨＰ是慢性浅表性胃炎的重要致病因素，其致病机制与ｓＩｇＡ保护作用有密切关系。
Objective To investigate the role of secretory immunoglobulin A (sIgA) in chronic superficial gastritis caused by Helicobacter pylori (HP). Methods Sixty-three patients with chronic superficial gastritis were selected and divided into mild, moderate and severe gastritis according to their histological classification. The patients were divided into active and inactive gastritis according to the presence or absence of neutrophil. Radioimmunoassay was used to determine sIgA, HP detection using urease test and Warthin-Starry staining. Results The detection rate of Helicobacter pylori in chronic superficial gastritis was 49.21%. Serum sIgA levels were significantly higher in patients with HP-positive gastritis than in those with HP-negative disease. Mild gastritis were significantly lower than moderate and severe, the difference was significant (P <0.001). Gastric fluid in patients with HP-positive active gastritis was significantly higher than in patients with HP-positive inactive gastritis. Conclusion HP is an important causative agent of chronic superficial gastritis. Its pathogenic mechanism is closely related to the protective effect of sIgA.