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选用健康豚鼠３６只，随机分为３组，第１组为庆大霉素组（ＧＭ组），第２组为庆大霉素 加二甲亚砜组（ＧＭ＋ＤＭＳＯ组），第３组为正常对照组，每组动物各１２只，用电反应测听仪及硫代 巴比妥酸荧光比色法检测庆大霉素组及庆大霉素加二甲亚砜组动物耳蜗听功能及耳蜗和血清中脂 质过氧化产物丙二醛（ＭＤＡ）含量。结果显示：ＧＭ＋ＤＭＳＯ组动物耳蜗神经动作电位（ＡＰ）阈值较 ＧＭ组明显降低，ＡＰ（Ｎ１）潜伏期ＧＭ组较ＧＭ＋ＤＭＳＯ组显著延长；ＧＭ组动物耳蜗中ＭＤＡ含 量较ＧＭ＋ＤＭＳＯ组明显为高（Ｐ＜０．０１）。提示：自由基引起耳蜗脂质过氧化可能与庆大霉素耳蜗 毒性有关。
Thirty-six healthy guinea pigs were randomly divided into three groups. The first group was gentamicin group (GM group), the second group was gentamycin plus dimethyl sulfoxide group (GM + DMSO group), the third group was normal In the control group, 12 animals in each group were used to measure the auditory function and cochlea of gentamicin group and gentamicin plus dimethylsulfoxide group by electroacoustic spectrometer and thiobarbituric acid fluorescent colorimetry. And serum lipid peroxidation product malondialdehyde (MDA) content. Compared with GM + DMSO group, the content of MDA in GM + DMSO group was significantly higher than that in GM + DMSO group (P <0. 05) .01). Tip: free radical induced cochlear lipid peroxidation may be related to gentamicin cochlear toxicity.