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内皮素(Endothelin,ET)是新近发现的一种由血管内皮细胞产生的含21个氨基酸的生物活性多肽,也是迄今所知体内最强的血管收缩肽,近年来,内皮素与心血管疾病的关系受到国内外学术界的共同关注。为此,我们对健康人与高血压、冠心病患者进行了血浆ET含量测定,现报告如下。 对象和方法 一、对象:冠心病组20例(男17例,女3例),年龄41～78(平均59.7)岁,诊断均符合1979年国际心脏病学会及世界卫生组织冠心病的诊断标准。高血压组25例(男16例,女9例),年龄50～80(平均62.7)岁,诊断根据WHO建议使用的高血压诊断标准。正常对照组49例(男39例,女10例),年龄40～71(平均57.9岁,均为健康体检者,经严格检查排除心、肺等系统疾病。 二、方法:采用放射免疫分析法。晨抽取肘静脉血于EDTA-Na_2抗凝管中,内含200ku/ml的抑肽
Endothelin (ET) is a recently discovered biologically active peptide with 21 amino acids produced by vascular endothelial cells. It is also the strongest known vasoconstrictor peptide in the body so far. In recent years, endothelin and cardiovascular diseases The relationship has drawn the common attention of academics at home and abroad. To this end, we have healthy people with hypertension, coronary heart disease in patients with plasma ET levels were reported as follows. Subjects and Methods 1. Subjects: Coronary heart disease group of 20 patients (17 males and 3 females), aged 41 to 78 (mean 59.7) years of age, the diagnosis is in line with the 1979 International Society of Cardiology and World Health Organization diagnostic criteria for coronary heart disease . Twenty-five hypertensive patients (16 males and 9 females) aged 50-80 years (average 62.7 years) were diagnosed according to WHO diagnostic criteria for hypertension. 49 cases of normal control group (10 males and 10 females), aged 40-71 (mean 57.9 years old, all healthy people, strict examination to exclude heart, lung and other diseases.) Second, the method of radioimmunoassay In the morning, elbow venous blood was drawn from EDTA-Na 2 anticoagulant tubes and contained 200 ku / ml of inhibitory peptide