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目的:探讨硝苯吡啶对低氧性肺动脉高压(HPH)的疗效观察。方法:在海拔5 000 m以上高原,对临床确诊的20例HPH患者口服硝苯吡啶10mg/次,每日2次,服用3个月,治疗前后采用超声心动图检测右室舒张末前后径(RVED)、右室前壁厚度(RVAW)、右室流出道(RVOT)、肺动脉主干内径(MPA)和三尖瓣反流,同时采血检测超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)及一氧化氮合酶(NOS)的含量。结果:治疗后较治疗前RVED、RVAW、RVOT、MPA降低,有非常显著性差异(P<0.05或0.01);三尖瓣反流发生率明显降低(P<0.01);治疗后较治疗前SOD、NOS、NO增高,MDA降低,有显著性差异(P<0.05或0.01)。结论:硝苯吡啶对低氧性低肺动脉高压具有一定的治疗作用,除钙拮抗外,还存在抗氧化作用。
Objective: To investigate the effect of nifedipine on hypoxic pulmonary hypertension (HPH). Methods: Twenty patients with HPH clinically diagnosed with HPH were treated with nifedipine 10 mg twice daily for 3 months before and after treatment. Before and after treatment, the anteroposterior diameter RVED, RVVA, RVOT, MPA and tricuspid regurgitation were measured at the same time. Blood samples were collected for determination of superoxide dismutase (SOD), malondialdehyde (MDA) ), Nitric oxide (NO) and nitric oxide synthase (NOS). Results: After treatment, RVED, RVAW, RVOT and MPA were significantly decreased (P <0.05 or 0.01), the incidence of tricuspid regurgitation was significantly decreased (P <0.01) , NOS, NO increased, MDA decreased, there was a significant difference (P <0.05 or 0.01). CONCLUSION: Nifedipine has a certain therapeutic effect on hypoxic pulmonary hypertension. In addition to calcium antagonism, there is also an anti-oxidative effect.