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目的:探讨阴道上皮内瘤样病变(VAIN)的临床及病理表现。观察5-FU局部注射治疗VAIN的疗效。方法:应用5-FU局部注射治疗VAIN2例。通过临床表现,阴道脱落细胞检查,阴道镜检查及病理检查,观察VIAN在治疗前后的表现。结果:5-FU局部注射治疗2例VAIN患者,治疗前后阴道断端多次脱落细胞检查均为阴性,阴道镜下醋酸试验及碘试验表现典型。应用5-FU局部注射治疗逆转了组织学异常改变。结论:①VAIN的诊断依靠病理组织学检查。阴道镜可以提高活检的准确性。②VAIN3级患者接受5-FU局部注射能逆转了组织学的异常改变。③发现生殖道一种上皮内瘤样病变或癌变时,应注意生殖道其它部位合并癌前病变或癌变的情况。
Objective: To investigate the clinical and pathological features of vaginal intraepithelial neoplasia (VAIN). To observe the effect of local injection of 5-FU on VAIN. Methods: Five cases of VAIN were treated with 5-FU local injection. Through clinical manifestations, vaginal exfoliated cells, colposcopy and pathological examination to observe the performance of VIAN before and after treatment. Results: Five cases of VAIN were treated with local injection of 5-FU. The number of exfoliated cells in vaginal septa was negative before and after treatment. The acetic acid test and iodine test in colposcopy were typical. Local injection of 5-FU reversed the histological abnormalities. Conclusion: ①VAIN diagnosis depends on histopathological examination. Colposcopy can improve the accuracy of biopsy. ② VAIN3 patients receiving 5-FU local injection can reverse the histological abnormalities. ③ reproductive tract found intraepithelial neoplasia-like lesions or cancer, attention should be paid to other parts of the genital tract with precancerous lesions or cancer.