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目的探讨多发性恶性血管内乳头状血管内皮瘤诊断及治疗情况。方法回顾性分析该院收治的多发性恶性血管内乳头血管内皮瘤患者,依照临床症状、组织学变化及免疫组化特征进行研究。结果患者病变部位发现明显肿瘤组织,呈现不规则扩张型薄壁管腔物,个别位置血管腔内发现乳头状皱起组织,免疫组化对管壁及乳头皱起组织检查发现其内皮细胞CD31、CD34和F8因子均显示阳性,但是管腔内海绵状组织内皮细胞组织学检验呈阴性。结论多发性恶性血管内乳头状血管内皮瘤较为罕见,主要依靠临床症状,组织学变化及免疫组化特征进行确诊,预后效果较为理想。
Objective To investigate the diagnosis and treatment of multiple malignant intravascular papillary hemangioendothelioma. Methods Retrospective analysis of patients with multiple malignant endovascular endothelium tumor treated in our hospital was conducted according to clinical symptoms, histological changes and immunohistochemical characteristics. Results Significant tumor tissue was found in the lesion, showing irregular expansion of thin-walled tube, papillary wringer tissue was found in the vascular cavity of individual position. Immunohistochemistry showed that endothelial cell CD31, Both CD34 and F8 showed positive results, but histological examination of spongy endocardial cells in the lumen was negative. Conclusions Multiple malignant endovascular papillary hemangioendothelioma is rare and mainly depends on the clinical symptoms, histological changes and immunohistochemical characteristics, and the prognosis is satisfactory.