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随机、对照、开放性临床试验评价硫酸爱大霉素治疗呼吸道及泌尿道细菌感染性疾病的临床有效性和安全性。硫酸爱大霉素为水针剂与粉针剂，选用奈替米星作对照。水针剂试验组与对照组各３０例，开放试验４０例。粉针剂试验组２１例，对照组２２例。给药方法两药均为１００ｍｇ／次，２次／ｄ，疗程７－１０ｄ。结果：水针剂：试验组与对照组临床有效率均为９０．０％，细菌清除率分别为８６．２％与８０％，药物不良反应发生率均为１０．０％。开放试验有效率、细菌清除率和药物不良反应发生率分别是８７．５％，７５．６％与１０．０％。粉针剂试验结果与水针剂近似。
Randomized, controlled, and open clinical trial evaluated the clinical efficacy and safety of avermectin sulfate in the treatment of respiratory and urinary tract bacterial infections. Ammonium sulfate for water injection and injection, the use of netilmicin as a control. Water injection test group and control group of 30 cases, 40 cases open trial. 21 cases were in the test group and 22 cases in the control group. Administration of two drugs are 100mg / time, 2 times / d, treatment 7-10d. Results: The water injection dose: The clinical effective rate was 90.0% in the test group and the control group, the bacterial clearance rates were 86.2% and 80% respectively, and the adverse drug reaction rates were 10.0%. Open trial efficiency, bacterial clearance and adverse drug reactions were 87.5%, 75.6% and 10.0% respectively. Injection test results and water injection similar.