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目的建立确定适用我国国情的化学物质和化妆品安全性分级标准和适用范围。方法同时采用HET-CAM法和动物试验对32种化学物、187种不同种类化妆品进行检验,以4种不同分级标准对检验结果进行分析比较。结果四种分级标准中第三种分级标准(0～6无/微刺激性、6.1～12轻刺激性、12.1～16刺激性、16.1～21腐蚀性)与动物试验的分级标准具有较高的等级相关性及一致性,且面膜类和眼部护肤类产品的结果一致性为最好。结论HET-CAM试验的分级标准采用第三种标准比较合适。面膜类和眼部护肤类产品可用HET-CAM法完全替代动物试验而对于洗面奶类、染发类、烫发类和洗发类的产品,只适宜作为筛选试验。
Objective To establish a classification standard and scope for the safety of chemical substances and cosmetics that are applicable to China’s national conditions. Methods HET-CAM method and animal experiment were used to test 32 kinds of chemicals and 187 kinds of different kinds of cosmetics. The test results were compared and analyzed with 4 different grading standards. Results The third of the four grading standards (0-6 without / micro-irritation, 6.1-12 with light irritation, 12.1-16 with 16.1-21 causticity) had higher Level of relevance and consistency, and the mask and eye skin care products the consistency of the results for the best. Conclusion HET-CAM test grading standards using the third standard is more appropriate. Mask and eye skin care products available HET-CAM method can completely replace animal experiments For the cleanser, hair type, perm class and shampoo products, only suitable as a screening test.