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目的评价森林脑炎灭活疫苗加强免疫后的免疫效果。方法选择吉林市森林脑炎发病率较高的蛟河市、舒兰市既往有森林脑炎疫苗基础免疫史的400名8岁及以上健康人群,于基础免疫后18个月,进行1剂加强免疫,加强免疫1个月后,采集受试者静脉血,分离血清,使用森林脑炎Ig G ELISA试剂盒测定血清Ig G抗体水平。结果 400名受试者中,失访61人,共339人完成加强免疫,男女比例为3.35∶1;抗体阳性325人,阳性率为95.87%,GMC为3 391 VIEU/ml,其中8~16岁、17~59岁及60岁以上年龄组抗体阳性率差异无统计学意义(P>0.05),但GMC差异有统计学意义(P<0.01),男、女抗体阳性率及GMC差异均有统计学意义(P<0.05)。结论受试者加强免疫后抗体阳性率较高,产生了高滴度的保护性抗体。
Objective To evaluate the immunization effect of vaccination with forest encephalitis after immunization. Methods A total of 400 healthy people aged 8 and above who had a history of basic immunization of forest encephalitis vaccine in Jiaohe City and Shulan City, Jilin Province were selected to have a higher incidence of forest encephalitis in Jilin City. One dose was boosted 18 months after the basic immunization. One month after the immunization and booster immunization, the venous blood of the subjects was collected, the serum was separated, and the serum Ig G antibody level was measured using the IgE ELISA kit of forest encephalitis. Results Among the 400 subjects, 61 were lost to follow-up and 339 were boosted. The ratio of male to female was 3.35:1. The antibody positive rate was 325, the positive rate was 95.87%. GMC was 3991 VIEU / ml, of which 8-16 There was no significant difference in the positive rate of antibody between the age of 17, 59 and 60 years (P> 0.05), but the difference of GMC was statistically significant (P <0.01) Statistical significance (P <0.05). Conclusion The positive rate of antibodies in the subjects after boosting was high, which resulted in high titers of protective antibodies.