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AIM: To investigate the expression of annexin I in pancreaticcancer and its relationship with the clinicopathologic factors,and to evaluate its potential clinical significance.METHODS: Annexin I expression was analyzed by Westernblot and irnmunohistochemical staining in pancreaticadenocarcinoma and multi-tissue microarrays (MTAs).RESULTS: Western blot analysis showed that annexin Iwas overexpressed in 84.6% (11/13) pancreatic ductaladenocarcinomas.Immunohistochemistry analysis ofpancreatic cancer in MTAs showed that annexin I proteinwas 71.4%(30/42) positive which was markedly increasedcompared with that in the tumor matched normal pancreastissues 18.4%(7/38) (P<0.01).In the meantime,the highexpression of annexin 1 was correlated with the poordifferentiation of pancreatic adenocarcinoma.CONCLUSION: Annexin 1 overexpression is a frequentbiological marker and correlates with the differentiation ofpancreatic cancer during tumorigenesis.
AIM: To investigate the expression of annexin I in pancreatic cancer and its relationship with the clinicopathologic factors, and to evaluate its potential clinical significance. METHODS: Annexin I expression was analyzed by Western blot and irnmunohistochemical staining in pancreatica denocarcinoma and multi-tissue microarrays (MTAs). RESULTS: Western blot analysis showed that annexin Iwas overexpressed in 84.6% (11/13) pancreatic ductaladenocarcinomas. Immunohistochemistry analysis of pancreatic cancer in MTAs showed that annexin I protein was 71.4% (30/42) positive which was markedly increased with that in the tumor matched In the meantime, the highexpression of annexin 1 was correlated with the poordifferentiation of pancreatic adenocarcinoma. CONCLUSION: Annexin 1 overexpression is a frequentbiological marker and correlates with the differentiation of pancreatic cancer during tumorigenesis.