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通过胃粘膜的损害与胃癌发生关系的实验研究,发现胃粘膜反复损害,常导致不全修复及再生型异型增生。后者有4个类型,即Ⅰ型(糜烂面型)、Ⅱ型(粘膜内型)、Ⅲ型(溃疡边缘型)及Ⅳ型(舌状型)。其中尤以Ⅱ型为多见。结果显示:①在不同实验组再生型异型增生的出现频率与腺癌发生率互为一致;②与始发癌在形态上可见移行过渡;③在异型病变的局部出现早期癌变;④由Ⅱ型癌变而来的早期胃癌常保持着癌巢为大量纤维组织所分隔和包绕的形态特征。本研究论证了再生型异型增生为胃癌的一型重要癌前病变。这型病变亦见于人体材料,因此认为有关其癌前意义应予以重新认识。
Through experimental studies on the relationship between gastric mucosal lesions and gastric cancer, it has been found that repeated gastric mucosal lesions often result in incomplete repair and regenerative dysplasia. The latter has four types, i.e. type I (erosive surface type), type II (intramucosal type), type III (ulcer type), and type IV (tongue type). Among them, Type II is more common. The results showed that: 1 in different experimental groups, the frequency of regenerative dysplasia coincided with the incidence of adenocarcinoma; 2 and the transitional transition of primordial carcinoma; 3 early lesions appeared in the heterogeneous lesions; 4 by type II Cancerous early gastric cancer often maintains a morphological feature in which the cancer nest is separated and surrounded by a large number of fibrous tissues. This study demonstrated that regenerative dysplasia is an important type of precancerous lesion of gastric cancer. This type of lesion is also found in human body material, so it is believed that the precancerous significance should be re-recognized.