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15例进展期胃癌患者于术前接受肠外营养支持.并于PNS前后分别通过胃镜及术中取正常胃粘模和胃癌组织.经FCM分析细胞周期各时相百分率的变化。同期作免疫功能测定:结果发现,PNS后,胃癌细胞的G_0/G_1%显著下降(P<0.01),S—G_2—M%则明显增加(P<0.025)。正常胃粘膜细胞无类似的变化。此外,PNS后自然杀伤细胞(NKC)活性有所增加,但以CD～+_4的增加最为显著(P<0.05)。提示:术前PNS有助于改善胃癌患者的免疫力,同时亦可能刺激肿瘤细胞增殖。因而,为在增殖期应用化疗提供了可行性。
Fifteen patients with advanced gastric cancer received parenteral nutrition support before operation. Before and after PNS, normal gastric mucosal models and gastric cancer tissues were obtained by gastroscopy and intraoperatively. Percentage changes of the cell cycle were analyzed by FCM. At the same time for the determination of immune function: the results found that after PNS, gastric cancer cells G_0/G_1% significantly decreased (P <0.01), S-G_2-M% was significantly increased (P <0.025). There is no similar change in normal gastric mucosal cells. In addition, the activity of natural killer cells (NKCs) after PNS increased, but the increase was most significant with CD-+_4 (P<0.05). Tip: Preoperative PNS helps to improve the immunity of gastric cancer patients, and it may also stimulate the proliferation of tumor cells. Thus, the feasibility of applying chemotherapy during the proliferative phase is provided.