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用超微结构细胞化学方法,观察55例胃粘膜活检组织中碱性磷酸酶(AKP)的分布特点及含量,发现在胃炎伴肠上皮化生组织中,AKP分布于细胞膜及腺腔的微绒毛;在不典型增生的组织中,除在细胞膜及微绒毛中观察到AKP外,部分病例还见于胞质;胃癌组织内AKP的分布与其组织学类型有关;在高分化腺癌中,AKP见于细胞膜上,而在低分化腺癌,则主要存在于胞质内。结果表明:不典型增生可能为肠上皮化生的一个连续过程,部分不典型增生与高分化腺癌有关,而另一部分不典型增生则与低分化腺癌关系密切。
Using ultrastructural cytochemical methods, the distribution characteristics and contents of alkaline phosphatase (AKP) in 55 cases of gastric mucosal biopsy were observed. It was found that in gastritis with intestinal metaplasia, AKP distributed in the cell membrane and glandular cavity microvilli In atypical hyperplasia, AKP was observed in cell membranes and microvilli. Some cases were also seen in cytoplasm; the distribution of AKP in gastric cancer tissues was related to histological type; in well-differentiated adenocarcinomas, AKP was found in cell membranes. On the other hand, in poorly differentiated adenocarcinoma, it mainly exists in the cytoplasm. The results showed that atypical hyperplasia may be a continuous process of intestinal metaplasia. Part of atypical hyperplasia is related to well-differentiated adenocarcinoma, and another part of dysplasia is closely related to poorly differentiated adenocarcinoma.