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应用抗马来微丝蚴抗原4B_1株单克隆抗体(McAb)和抗马来成虫代谢抗原4B_7株McAb酶联免疫吸附试验(ELISA)检测班氏微丝蚴血症者血清中循环抗原,阳性率分别为78.46％(102/130)和87.13％(88/101);检测51例晚期丝虫病人血清,阳性率分别为3.92％和1.96％;36例经治疗后微丝蚴血症阴转者血清,阳性率分别为13.89％和8.33％。丝虫病非流行区99例肠道蠕虫感染者阳性率分别为16.16％和5.05％。结果表明抗马来成虫代谢抗原4B_7株McAb应用于诊断班氏丝虫感染的效果优于抗马来微丝螺4B_1株McAb。
The anti-Malassezia filariasis McAb 4B_1 monoclonal antibody (McAb) and the anti-Malay adult metabolic antigen 4B_7 McAb enzyme-linked immunosorbent assay (ELISA) detection of Bancrofti microfilariae serum of circulating antigens, the positive rate Respectively, which were 78.46% (102/130) and 87.13% (88/101), respectively. Serum samples from 51 patients with late filariasis were detected with the positive rates of 3.92% and 1.96%, respectively. Thirty-six of the 36 patients with microfilaremia were negative Serum, the positive rates were 13.89% and 8.33%. The positive rates of gut worm infection in 99 cases of filariasis non-endemic area were 16.16% and 5.05% respectively. The results showed that the McAb 4B7 against maternal adult metabolites of B. bilineata was superior to McAb BB 4B_1 in diagnosing Bancroftian’s filariasis infection.