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呋哺坦丁(Nitrofurantoin)是广泛应用于治疗泌尿道感染的药物,服后迅速由尿中排泄,血浓度很低.通常副作用较少.最常见的副作用力发热,白细胞减少、溶血性贫血、肺纤维化、外周神经炎和胆汁淤滞性黄疸.1975年Klemola等首次报告4例病人应用呋喃坦丁9周至9个月后引起血清转氨酶升高,高丙种球蛋白血症,肝活检呈典型的慢性活动性肝炎(CAH)的病理改变,停止治疗后2~6周血清转氨酶恢复正常.嗣后这方面的报告主要来自斯堪的纳维亚地区,近来美国也陆续发现这类病人.由于呋喃坦丁为常用药物,故作简要综述.
Nitrofurantoin is widely used in the treatment of urinary tract infections and is rapidly excreted by the urine after it is given, with low blood concentrations, usually with fewer side effects, the most common side effects of fever, leukopenia, hemolytic anemia, Pulmonary Fibrosis, Peripheral Neuritis and Cholestatic Jaundice. In 1975, for the first time, Klemola et al reported 4 cases of patients using furanetin 9 to 9 months after the rise of serum transaminases, hypergammaglobulinemia, liver biopsy was typical Chronic active hepatitis (CAH) pathological changes, stop the treatment 2 to 6 weeks after the return of serum aminotransferases.Further reports in this area mainly from Scandinavia, the United States has also been found in recent patients such as furan Tan Ding is commonly used drugs, so for a brief review.