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一,硒在抗癌治疗中的作用 含硒酶:谷胱甘肽过氧化物酶(GSH—Px)可保护正常组织防止阿霉素等抗癌药物引起自由基或过氧化物生成所产生的毒性。阿霉素抗瘤谱广、疗效强,已广泛应用,但可受酶还原成半醌,从而将分子氧还原,导致毒性自由基连锁反应,伤害细胞膜及去氧核糖核酸(DNA)。其限制剂量的是心脏毒性,因为心肌中几乎没有触酶,其过氧化物歧化酶水平只相当于
First, the role of selenium in anti-cancer treatment Selenium-enzyme: glutathione peroxidase (GSH-Px) can protect normal tissues against the production of free radicals or peroxides caused by anticancer drugs such as adriamycin toxicity. Doxorubicin has broad anti-tumor spectrum and strong curative effect. It has been widely used, but it can be reduced by enzymes into semi-quinones, thereby reducing molecular oxygen, leading to toxic free radical chain reactions, and damaging cell membranes and deoxyribonucleic acid (DNA). The limiting dose is cardiotoxicity because there is almost no catalase in the heart muscle and the superoxide dismutase level is only equivalent to