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采用超临界CO_2技术制备了一种联苯双酯的硅负载固体分散体(silica-supported solid dispersion),以增强药物的溶出速度和口服生物利用度。采用差示扫描量热法(DSC)、X射线衍射法(XRD)和扫描电镜(SEM)进行表征。结果表明,当联苯双酯与二氧化硅的比例为1∶15和1∶19时,所得固体分散体中药物以无定形形式存在。体外溶出试验结果显示,制品中联苯双酯的溶出速率显著提高,20 min内溶出率达到67%,而联苯双酯与二氧化硅的物理混合物及市售滴丸(一种以聚乙二醇6000为载体的常规联苯双酯固体分散体)的溶出率为8%和
A silica-supported solid dispersion of bifendate was prepared using supercritical CO 2 technology to enhance drug dissolution rate and oral bioavailability. The samples were characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results show that when the ratio of bifendate to silica is 1:15 and 1:19, the drug in the resulting solid dispersion exists in an amorphous form. In vitro dissolution test results showed that the dissolution rate of bifendate significantly increased in products within 20 min dissolution rate of 67%, and the physical mixture of bifendate and silica and commercially available dropping pills (a polyethylene The conventional diphenyl ester solid dispersion with diol 6000 as carrier) had a dissolution rate of 8%