Nociceptive behavioural assessments in mouse models of temporomandibular joint disorders

• 作 者: Jun Li Kaige Ma Dan Yi Chun-do Oh Di Chen
• 机 构: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA;Research Ce
• 出 处: 国际口腔科学杂志（英文版）
• 发表日期: 2020年3期

INTRODUCTIONrnThe temporomandibular joint (TMJ) is one of the most frequently used joints in the human body,1 and TMJ disorders (TMDs) are commonly encountered in dental clinical practice, with a prevalence of 4％–10％ worldwide.2–3 TMD patients present with at least one of the following symptoms:pain, mandibular mobility limitations, TMJ noise, and clicking. Orofacial pain is a primary clinical complaint reported by patients who seek treatment.4–5 Although several mouse models have been developed to explore the pathological mechanisms underlying TMDs, few feasible approaches for assessing nociceptive behaviours in the orofacial region have been developed in mice. Behavioural alterations, especially nociceptive phenotypes, are key clinical indicators for determining the similarity between animal models and human TMDs and are important for evaluating the efficacy of drug therapy.