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目的 探讨 2型糖尿病中谷氨酸脱羧酶抗体 (GAD -Ab)与急性时相反应标记物之一C -反应蛋白 (CRP)之间的联系。 方法 对 1 1 2例 2型糖尿病患者进行GAD -Ab和CRP测定。 结果 GAD-Ab阳性组其CRP值较GAD -Ab阴性组明显升高。 结论 炎症是与胰岛 β细胞功能和结构缺陷有关的自身免疫反应的一部分。胰岛细胞自身免疫反应的存在是与急性时相胰岛素分泌的紊乱有关的。
Objective To investigate the association between glutamate decarboxylase antibody (GAD-Ab) and C-reactive protein (CRP), an acute phase response marker in type 2 diabetes mellitus. Methods 112 cases of type 2 diabetes patients were measured GAD -Ab and CRP. Results The CRP value of GAD-Ab positive group was significantly higher than that of GAD-Ab negative group. Conclusion Inflammation is part of an autoimmune response that is associated with pancreatic β-cell function and structural defects. The presence of islet cell autoimmune responses is related to the disorder of acute phase insulin secretion.