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目的：观察分析小剂量阿司匹林（ａｓｐｉｒｉｎ， ＡＳＡ，每天≤１００ ｍ ｇ） 对老年人胃、十二指肠粘膜的损伤。方法：ＡＳＡ组４１ 例，未服药对照组９６ 例，对照分析两组老年人胃、十二指肠粘膜病变胃镜检出率。结果：ＡＳＡ组胃粘膜病变的检出率（５８．５％ ） 高于对照组（３５．４％ ） 有显著性差异（Ｐ＝ ０．０１２），两组间十二指肠粘膜病变检出率（分别为４．９％ 和５．２％ ） 无显著性差异（Ｐ＝ ０．９３６）；进一步分析显示ＡＳＡ组和对照组浅表粘膜病变（糜烂和出血性胃炎）检出率为５１．２％ 和３２．３％ ，有显著性差异（Ｐ＝ ０．０３７），两组间溃疡检出率（分别为９．８％ 和９．４％ ）无显著性差异（Ｐ＝ ０．９９４）。结论：服用小剂量ＡＳＡ对老年人胃粘膜有损伤作用，主要引起浅表粘膜病变（糜烂和出血性胃炎）。
OBJECTIVE: To observe and analyze the damage of stomach and duodenal mucosa in elderly patients with aspirin (ASA, ≤100 m g daily). Methods: 41 cases of ASA group and 96 cases of non-medication control group, the detection rate of gastroscopy in gastric mucosa and duodenal mucosa in two groups were compared. Results: The prevalence of gastric mucosal lesions in ASA group (58.5%) was significantly higher than that in control group (35.4%) (P = 0.012). Duodenal mucosal lesions were detected in two groups (4.9% and 5.2% respectively) (P = 0.936). Further analysis showed that the detection rates of superficial mucosal lesions (erosion and hemorrhagic gastritis) in ASA group and control group were 51 .2% and 32.3%, respectively (P = 0.037). There was no significant difference in the detection rate of ulcer between the two groups (9.8% and 9.4% respectively) (P = 0. 994). CONCLUSIONS: A small dose of ASA has a damaging effect on the gastric mucosa of the elderly and mainly causes superficial mucosal lesions (erosions and hemorrhagic gastritis).