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目的 探讨纤维连结蛋白（ＦＮ） 在结肠癌和直肠癌组织中的变化及其与结直肠癌生物学行为的关系。方法 采用免疫组化对结肠粘膜活检及结肠癌和直肠癌手术标本进行了ＦＮ 的定位观察。结果 ＦＮ 见于肠粘膜上皮细胞、部分癌细胞内以及基底膜、间质中。异型增生上皮细胞ＦＮ 染色增强，癌细胞和其基膜ＦＮ 减少缺失且与癌细胞分化程度相关，癌间质ＦＮ 丰富。结论 ＦＮ 可分为上皮细胞型ＦＮ（ 细胞ＦＮ 和基膜ＦＮ） 和间质细胞型ＦＮ（ 间质ＦＮ） ，两者在结直肠癌侵袭转移中作用不同。
Objective To investigate the changes of fibronectin (FN) in colon and rectal cancer tissues and its relationship with the biological behavior of colorectal cancer. Methods Immunohistochemistry was used to observe the colon mucosal biopsy and colon cancer and rectal cancer surgical specimens. Results FN found in intestinal epithelial cells, some cancer cells and the basement membrane, interstitial. FN staining enhanced dysplasia epithelial cells, cancer cells and their basement membrane FN decreased and associated with the degree of differentiation of cancer-related, interstitial FN rich. Conclusion FN can be divided into epithelial cell FN (FN and FN) and interstitial FN (interstitial FN), both of which play different roles in invasion and metastasis of colorectal cancer.