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目的探讨参术冠心通颗粒治疗稳定性心绞痛患者的生存质量。方法选取2013年3月—2016年3月本院治疗的冠心病稳定性心绞痛患者90例作为研究对象,随机分为观察组和对照组各45例。两组均进行抗血小板、控制血压、缓解心绞痛等治疗。观察组:参术冠心通颗粒剂。对照组:参术冠心通颗粒剂安慰剂。西雅图生存质量评分表SAQ评价患者生活质量。比较两组治疗前后TC、TG、LDL-C变化。计量资料比较采用两独立样本t检验和配对t检验,P<0.05为差异有统计学意义。结果治疗后,观察组躯体受活动限制维持度、心绞痛稳定情况维持度、心绞痛发作状态维持度、治疗结果满意维持度[(63.45±4.16)、(80.32±13.78)、(87.96±9.64)、(96.58±6.67)分]均明显高于对照组[(58.56±3.47)、(69.57±11.24)、(76.42±10.35)、(82.36±9.53)分],差异均有统计学意义(均P<0.05)。治疗后两组患者的西雅图生存质量各评分均高于治疗前,差异均有统计学意义(均P<0.05)。治疗后两组患者TC、LDL-C[(4.15±0.26)、(2.58±0.46)mmol/L与(5.23±0.35)、(2.93±0.68)mmol/L]比较,差异均有统计学意义(均P<0.05)。两组患者治疗后TC、TG、LDL-C均显著低于治疗前,差异均有统计学意义(均P<0.05)。结论参术冠心通颗粒治疗稳定性心绞痛,可以明显提高患者的生活质量,降低血脂。
Objective To investigate the quality of life of patients treated with Guanshuantongtong Granule in patients with stable angina pectoris. Methods 90 patients with stable angina pectoris in our hospital from March 2013 to March 2016 were selected as study subjects and randomly divided into observation group and control group with 45 cases each. Both groups were antiplatelet, blood pressure control, angina pectoris and other treatment. Observation group: Senate Guanxintong granules. Control group: Ginseng Guanxintong granules placebo. Seattle Quality of Life Questionnaire SAQ evaluates patient quality of life. The changes of TC, TG and LDL-C before and after treatment were compared between the two groups. Measurement data were compared using two independent samples t test and paired t test, P <0.05 for the difference was statistically significant. Results After treatment, the body was restrained by activities, the stability of angina pectoris, the state of angina pectoris and the satisfaction of the treatment were satisfied [(63.45 ± 4.16), (80.32 ± 13.78), (87.96 ± 9.64), ( 96.58 ± 6.67) were significantly higher than those in the control group (58.56 ± 3.47, 69.57 ± 11.24, 76.42 ± 10.35, 82.36 ± 9.53, respectively) (all P <0.05 ). After treatment, the quality of life of the two groups in Seattle scores were higher than before treatment, the difference was statistically significant (P <0.05). After treatment, the differences of TC, LDL-C [(4.15 ± 0.26), (2.58 ± 0.46) mmol / L vs (5.23 ± 0.35), (2.93 ± 0.68) mmol / L] in the two groups were statistically significant All P <0.05). After treatment, TC, TG and LDL-C in both groups were significantly lower than those before treatment (all P <0.05). Conclusion Guoshuantong Granules treatment of stable angina can significantly improve the quality of life of patients and reduce blood lipids.