Solid-phase synthesis of huwentoxin-I and its structure and bioactivity analysis

• 作 者: 梁宋平 夏赞贤 谢锦云
• 机 构: DepartmentofBiology,HunanNormalUniversity,Changsha410081China,Changsha410081China
• 出 处: 中国科学：生命科学英文版
• 发表日期: 1997年5期
• 关键词: huwentoxin-I SOLID-PHASE method. huwentoxin-I solid-phase method.
• 基金项目: Project supported by the National Natural Science Foundation of China and Hunan Educational Committee.

Huwentoxin-I, a neurotoxic peptide from the spider Selenocosmia huwena, was synthesized by sol-id-phase method with Fluorenylmethoxycarbonyl amino acid pentafluorophenyl esters (Fmoc-AA-OPfp). The carboxyl and the hydroxy groups were protected by tBu; the