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颅咽管瘤的细胞来源理论主要有两个:一、源于鳞状上皮巢。二、Rathke’s裂囊肿。本实验的目的是通过垂体和颅咽管瘤中HCG样肽和PGP免疫组化定位确定颅咽管瘤的细胞来源。 作者用过氧化酶免疫组化方法检查了5例正常腺垂体和23例颅咽管瘤病人的HCG和PGP分布情况。在正常腺垂体中大多数的鳞状上皮巢和中介细胞被抗HCG—α。和抗HCG—β抗体染色。少量的腺垂体细胞也对抗HCG—β日抗体呈阳性反应。PGP阳性细胞散布于前叶,但鳞状上皮细胞巢对抗PGP抗体呈阴性反应。一定数量的中介细胞和Rathke’s边缘细胞也被PGP抗体染色。星形滤泡细胞、Rathke’s囊、中介细胞和鳞状上皮巢呈角蛋
Craniopharyngioma cell source theory there are two: First, from the squamous epithelium. Second, Rathke’s cracked cyst. The purpose of this experiment is to determine the cellular source of craniopharyngioma by immunohistochemical localization of HCG-like peptide and PGP in pituitary and craniopharyngiomas. The authors used peroxidase immunohistochemistry to examine the distribution of HCG and PGP in 5 normal pituitary and 23 craniopharyngioma patients. In normal pituitary gland most squamous epithelial neoplasms and intervening cells are resistant to HCG-α. And anti-HCG-β antibody. A small amount of adenohypophyseal cells are also positive for anti-HCG-β antibody. PGP-positive cells scattered in the anterior lobe, but squamous cell nests against PGP antibodies were negative. A number of mediating cells and Rathke’s marginal cells are also stained with PGP antibodies. Star-shaped follicular cells, Rathke’s sac, mesothelial cells, and squamous epithelium are corneas