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本研究选用Ｗｉｓｔａｒ系雄性大鼠，通过向鼠脑的无名质区注射Ｉｂｏｔｅｎｉｃａｃｉｄ，造成中枢胆碱能系统破坏的动物模型。采用放免方法，测定了无名质区破坏后大鼠不同脑区ＣｈＡＴ活性和ＳＳ含量的变化。结果发现：大鼠一侧无名质区破坏后，同侧大脑皮质额叶，顶叶的ＣｈＡＴ活性显著下降，同时同侧额叶、顶叶及海马的ＳＳ含量也明显降低。结果提示：中枢胆碱能系统和生长抑素系统有极密切的关系，无名质区破坏后脑内ＳＳ含量的下降，可能是伴随着胆碱能系统损伤的继发性改变。推测ＳＳ系统可能接受胆碱能系统的传入，参与对学习、记忆的调节。
In this study, Wistar male rats were selected and injected into Iblogenicacid in the immature area of the brain to establish the animal model of central cholinergic system destruction. The radioimmunoassay method was used to determine the changes of ChAT activity and SS content in different brain regions of rats after the destruction of the unknown area. The results showed that there was a significant decrease of ChAT activity in frontal lobe and parietal lobe of ipsilateral cerebral cortex when the rat was unnamed damaged, and the content of SS in ipsilateral frontal lobe, parietal lobe and hippocampus was significantly decreased. The results suggest that the central cholinergic system and the somatostatin system have a very close relationship, the destruction of the unstructured placental brain content of SS decreased may be accompanied by secondary changes in cholinergic system damage. Speculated that the SS system may accept the introduction of cholinergic system, involved in learning, memory regulation.